Please keep in mind that this guide is not intended to replace a face-to-face evaluation with your doctor. Chapman et al. There are several autoimmune diseases that will cause positive ANA resultsPBC, Sjogren's, RA, etc. Call your doctor or 911 if you think you may have a medical emergency. Learn more about the many benefits and features of joining Harvard Health Online , Find the best treatments and procedures for you, Explore options for better nutrition and exercise. Purde MT, Niederer R, Wagner NB, Diem S, Berner F, Hasan Ali O, Hillmann D, Bergamin I, Joerger M, Risch M, Niederhauser C, Lenz TL, Frh M, Risch L, Semela D, Flatz L. J Cancer Res Clin Oncol. But some people have positive ANA tests even when they're healthy. Other types of HPV cause: Flat warts. The staining pattern is loosely associated with autoimmune diseases, but certain situations may be more frequently seen. Does that mean I have lupus? These specific nuclear antibodies are themselves associated with specific autoimmune diseases. Ten percent of individuals worldwide are affected by autoimmune diseases, with systemic lupus erythematosus (SLE) being one of the most common. FYI that other less than 1% usually have a positive SSA, they have a problem with their complement system, or they have a lot of protein in their urine (nephrotic syndrome). 5 mnths PP with 3rd baby, weird neuro symptoms started 1 week PP, extensive W/U (blood & imaging), all normal except ANA & EBV. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health, plus the latest advances in preventative medicine, diet and exercise, pain relief, blood pressure and cholesterol management, andmore. Ketamine for treatment-resistant depression: When and where is it safe? In addition, there are several types of ANAs and, when necessary, additional testing can identify the specific type of ANA (also called subtype). PMC 100 But in simple terms, an ANA is an antibody directedtowards the nucleus of a cell. Now that we understand what an ANA actually is, we can now start to approach the subject of clinical significance AND when you should be tested. I had some blood work done and came back with positive Ana . They are very useful as serological markers for different autoimmune disease, like systemic lupus erythematosus (SLE), Sjgren's syndrome (SS), scleroderma, polymyositis, or mixed connective tissue disease. Healthy cells grow and multiply at a set rate, eventually dying at a set time. As people become more aware of how traditional cleaning products can . Our mission is to provide practice-focused clinical and drug information that is reflective of current and emerging principles of care that will help to inform oncology decisions. Front Immunol. At a dilution of 1:160, only 5 percent of normal individuals have a positive test for ANA. Geng R, Huang X, Li L, Guo X, Wang Q, Zheng Y, Guo X. Can vitamin D deficiency cause positive ANA? The new criteria require that the test for antinuclear antibody (ANA) must be positive, at least once, but not necessarily at the time of the diagnosis decision because an ANA can become negative with treatment or remission. Mikrobiyol Bul. These are all chronic diseases, and, if there is a life-threatening complication, the complication could be serious. ANA can be positive in upto 27% cancer patients. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. No symptoms of any disease, blood etc. Polyarteritis Nodosa This condition makes the blood veins to swell and destroys the body organs. Controls had ANA positivity in 5.4% and when compared with . The HPV strains that cause warts, including genital warts, are nuisances. Tobacco use is the primary cause of adenocarcinoma and other types of cancer. Lupus is a chronic (long-lasting) disease that affects many parts of the body, including the joints, skin, heart, lungs, blood vessels, kidneys, and brain. Are of old age, of above sixty-five years, especially for women. Dr. Bennett Machanic and another doctor agree. IBC tends to occur in younger women (younger than 40 years of age). The test for anti-nuclear antibodies is called the immunofluorescent antinuclear antibody test. ANA positivity has been associated with vitamin D deficiency in autoimmune disease patients (15-17), but little is known about vitamin D and ANA in healthy populations. ANA can be detected efficiently and sensitively by indirect immunofluorescence (IIF) when suspecting an autoimmune disease (AID). In fact, specificity is low, meaning that many healthy people have a positive result. So someone runs an ANA just because and its positive. An ANA test detects antinuclear antibodies (ANA) in your blood. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Accessibility Unlikely: ANA is an inflammatory marker for several things such as rheumatologic diseases (e.g. Question: The Papanicolaou (Pap) test is used to screen for which cancer? Abnormal cells grow and multiply out of control, and they don't die. Goodell's sign (cervical softening at 4wk), Chadwick's sign (blue color of vagina & cervix at 6-8 wk), enlarged uterus, (+) urine or blood pregnancy test. Accessibility Let me explain: The titer is the level to which the patients blood sample can be diluted and will still show positive ANA staining. Palliative care frightens some people: Heres how it helps, Parents don't always realize that their teen is suicidal. Shift work can harm sleep and health: What helps? There are many autoimmune diseases, so this test is like an ENTRY tool or a screening tool for autoimmune illnesses when there is suspicion. 2002 Dec;153(8):520-9. National Library of Medicine Accessed June 7, 2017. Depending on your symptoms and other, /diagnostic tests, the ANA could also be increased in the case of cancer but most likely, usually means nothing. Cancer cannot be diagnosed from ana. Now I will discuss the most common five causes of a positive ANA that I see in. Medications are foreign substances for our bodies. I was just told i have an elevated positive ana level (1/80) should i be concerned about cancer? Cancers that are associated with blood loss, such as colon cancer and cervical cancer. Medications are notorious for causing positive ANA tests; some can even cause lupus, which we call drug-induced lupus. You can return to your usual activities immediately. What medications can cause a positive ANA? Your immune system normally makes antibodies to help you fight infection. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. Remember that if you have many symptoms and a higher ANA titer, you must be seen by a rheumatologist. When antibodies attack cells in your body, such as in your joints, they can cause swelling and redness known as inflammation. Positive ANA, dsDNA, and ANCA in Malignancies Robert Fox, MD Disclosures August 30, 2002 Question In certain malignancies, patients may have positive antinuclear antibodies (ANA),. This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. Almost all patients with lupus have a positive ANA test. Stay on top of latest health news from Harvard Medical School. . An ANCA test is most often used to find out if you have a type of autoimmune vasculitis. You must meet 4 out of the 11 to have lupus. Some of the organisms which are harmful and tend to invade the body include viruses, bacteria, and microbes. Don't miss your FREE gift. As a specialist, I evaluate many patients based on clinical signs and symptoms, plus additional testing, I can also diagnose an autoimmune disease in my area of expertise. 2023 HealthCheckUp.com. Cancer? Is the ANA pattern suggestive of a specific disease? I am an otr cdl-a professional truck driver who has been in dispute with labcorp since february 2021 in regards to a positive drug test in question. 2022 Nov 30;13:1037504. doi: 10.3389/fimmu.2022.1037504. Close more info about Positive Anti-Nuclear Antibody (ANA) Test, Monoclonal Protein on Serum Protein Electrophoresis (M Component). If you've had radiation therapy in the past, you have a higher risk of developing . These conditions include elevated blood pressure, high blood sugar, excess body fat around the waist, high cholesterol and triglyceride levels. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. These are diseases where your body's immune system attacks some of your healthy cells. Having a positive ANA with a speckled pattern does not necessarily mean one has an AI. Craig et al4 found an ANA titer of at least 1:64 in 15% of healthy women younger than Neoplastic diseases may cause positive ANA. To continue reading this article, you must log in. If you believe that the posting of any material infringes your copyright, be sure to contact us through the contact form and your material will be removed! If you tested positive for mage4 on a early cdt lung blood test and have +ana 1:640 and elevated sed. What causes positive ANA besides autoimmune disease? These diseases may be types of cancer that cause positive ANA. The goal of this guide is to provide information while awaiting evaluation with your doctor, or for additional information after you have seen him or her. suggests a possible rheumatologic disorder. There are antibodies in the blood that can be found in many, but not all patients with the Sjgren's . 01). IBC is more common among women who are overweight or obese. This ANA pattern tends to be associated with specific antibodies as opposed to a homogenous pattern ANAs. Kaposi sarcoma is a cancerous tumor that develops from the cells lining the lymphatic or blood vessels. There is clearly increased risk of cancers amongst patients of autoimmune diseases compared to general population. Mourksi NE, Dalban C, Colombe-Vermorel A, Odeyer L, Simioni V, Frenel JS, Fabbro M, Bazan F, Abadie-Lacourtoisie S, Coquan E, Martinez S, Garin G, Tabone-Eglinger S, Treilleux I, Chabaud S, Prol D, Ray-Coquard I, Heudel PE, Diaz JJ, Marcel V. Mol Oncol. IBC tends to be more aggressiveit grows and spreads much more quicklythan more common types of breast cancer. If your doctor has ordered an antinuclear antibody (ANA) test, it's because they're looking for signs of an autoimmune disease. The Licensed Content is the property of and copyrighted by DSM. ATTENTION TO RIGHT HOLDERS! Please login or register first to view this content. The most common adenocarcinoma causes include: Smoking. It can also be positive in healthy people, though. https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antinuclear-Antibodies-ANAhttp://www.rheumatology.org/Practice/Clinical/Patients/Diseases_And_Conditions/Antinuclear_Antibodies_%28ANA%29/. Many cancers don't have symptoms until too late and Doctors will not even think that until the last resort when everything else has been checked meanwhile months and yrs. Subscribe to Harvard Health Online for immediate access to health news and information from Harvard Medical School. Not terribly helpful right? Assistant Professor in Pulmonary Medicine, GMERS Medical College, Ahmedabad, Pros And Cons Of Hormone Therapy For Breast Cancer, Testicular Cancer Test Types, Causes, Diagnosis, And Treatment. So what does that mean? Gene expression analysis in endometriosis: Immunopathology insights, transcription factors and therapeutic targets. In general, the more abnormal result, (that is, the higher the second number), the more likely it is to be meaningful; however, exceptions are common. Your doctor runs an ANA and it comes back as 1:320 speckled pattern. They can appear in your bloodstream when your immune system is fired-up to fight something foreign like viruses, bacteria, or a medication. More studies are needed to understand the real value of this finding. Malignancies can present as autoimmune diseases or they can mimic flare of Rheumatological diseases. 2 Since then, more than 90 medications from more than 10 drug classes have been . You may get a positive result if: You have SLE (lupus). Non-headache symptoms may include nausea, vomiting, and sensitivity to light, sound, or smell. 1996 Dec;95(12):905-10. Unable to load your collection due to an error, Unable to load your delegates due to an error, Prevalence of antinuclear antibodies (ANA) in patients with breast tumours and controls. There is no Doctor Patient relationship established. Autoantibodies against proteins located in the nucleus are called antinuclear antibodies (ANA). Rheumatologist OnCall is a telemedicine company that offers support, diagnostic, and the most advanced therapeutic options for your disease affordably and transparently when you need it the most. Chapman et al. The antinuclear antibody (ANA) test can show if your immune system is more likely to make the autoantibodies of lupus. Autoimmun Rev. One is more predisposed to get a positive test if they; Some medications cause a positive ANA or they highly suspected to lead to lupus condition they include birth control pills or Estrogens, Danazol, Mesalazine, Reserpine, Griseofulvin, Clonidine, Hydroxyurea Gemfibrozil, Allopurinol, Quinine, Minoxidil, Calcium channel blockers, Amiodarone, Spironolactone, Clozapine, Tocainide, Zafirlukast, Omeprazole among others. We strongly advised you to speak with your medical professional if you have questions concerning your symptoms, diagnosis and treatment. Want to view more content from Cancer Therapy Advisor? Why are cancer cells less dependent on growth factors? The examiner will take this into consideration as an existence of the autoimmune condition in that person being examined for the same. As a physician I care about symptoms and signs way more than lab tests. Sjgren's syndrome a disease that causes dry eyes and mouth. Conditions that usually cause a positive ANA test include: Conclusion: In conclusion, ANA and related autoantibodies can frequently be detected during lymphoma treatment. Cancer cannot be diagnosed from ana. Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight lossfrom exercises to build a stronger core to advice on treating cataracts. can go by and then it is too late to treat So I would encourage you to do all the research you can . This decision guide is designed for persons with a positive antinuclear antibody (ANA) who would like to find out more about this test and what the test result may mean. Int J Dermatol. We want you to take advantage of everything Cancer Therapy Advisor has to offer. Would you like email updates of new search results? Also it is important to note that antinuclear antibodies (ANA) are sometimes found in patients with autoimmune thyroid diseases. As we discussed, positive ANA can be seen in many autoimmune diseases: Autoimmune diseases are the most frequent cause of a positive ANA. The lymphatic network is made up of lymph nodes or lymph nodes, the spleen, thymus gland, and the bone marrow. Certain cancers and specific medications may also cause a positive ANA titer blood test. In this review, we are going to describe all data reported about the presence of these antibodies in samples from patients with cancer as well as the potential role of some of these proteins in early detection and prognosis. [] Having a ANA with a nucleolar pattern [], [] This is a huge change from the previous set of diagnostic criteria. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Would you like more information about the ANA test in general, or would you rather proceed directly to what your ANA may mean? Aliases & Classifications for Dermatographia MalaCards integrated aliases for Dermatographia: Cancer Census gene in COSMIC. . When antibodies attack cells in your body, such as in your joints, they can cause swelling and redness known as inflammation. e answer is NO. The relationship between antinuclear antibody data and antibodies against extractable nuclear antigens in a large laboratory cohort. Scleroderma or systemic sclerosis: ANA pattern is most commonly speckled, followed by centromeric and less commonly nucleolar Mixed connective tissue disease: ANA pattern is almost always. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Indirect immunofluorescence antibody technique, having a high sensitivity, is the most common technique used for detection, results of which are expressed in terms of the pattern of fluorescence, substrate used, and the titer of a positive test. It sounds like you might have some autoimmune process (although anas are notorious for false positives) which could explain your sedimentation rate. Interleukin-13 in autoimmune rheumatic diseases: relationship with the autoantibody profile. Deng C, Wang A, Hu C, Zhang W, Zeng X, Fei Y. About 2 out of 3 breast cancers are hormone receptor-positive. Lupus) and other chronic illnesses. HHS Vulnerability Disclosure, Help Patients with lupus have many other symptoms besides the fact that they have a positive ANA test. MeSH If youve read my earlier post, 8 important warning signs of scleroderma, youll remember that Raynauds phenomenon is an important red flag for scleroderma. Antinuclear antibodies (ANAs) are a spectrum of autoantibodies targeted to various nuclear and cytoplasmic components of the cells. You need a rheumatology consultation in those cases with many other associated symptoms. Enter your email address to subscribe to this blog and receive notifications of new posts by email. And remember, doctors treat people not numbers. An ANA test requires a sample of your blood. eCollection 2022. Are already prescribed to blood pressure or anti-seizure medications. Common warts. So is it safe to say if you have a speckled ANA that you definitely have an AI disease? Cancer can present as vasculitides, CTDs, myositis or arthritides. The blood of every human being has antibodies that are for fighting off other harmful organisms from invading our bodies. Please note the date of last review or update on all articles. Scleroderma This is a condition that affects the connective tissue. Swollen joints ( arthritis) Constant or severe fatigue Skin rash Ankle swelling Pain in your chest when breathing deeply ( pleurisy) A butterfly-shaped rash across your cheeks and nose (malar rash). Bethesda, MD 20894, Web Policies Your doctor is likely to order an ANA test for a suspected autoimmune disease such as lupus, rheumatoid arthritis or scleroderma. ANA patterns - Homogeneous, Nucleolar, Speckled and Centromere pattern At times, laboratories testing ANA also report a "pattern". If you were exposed to radiation or radiation therapy, you might also have a positive ANA. These include lupus, scleroderma, and rheumatoid arthritis. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A single copy of these materials may be reprinted for noncommercial personal use only. Copyright 2016 - 2022 All Rights Reserved. I had had a negative ANA in 2015 during a rough HG pregnancy when my Drs were trying to rule out factors. Studies find ANA positivity common, even in healthy people De Vlam and colleagues3 studied 485 healthy volunteer blood donors and found that 20% of the women and 7% of the men had a positive ANA result. Ultimately, clinical features are most important. Mayo Clinic does not endorse companies or products. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. Cinoku I, Mavragani CP, Tellis CC, Nezos A, Tselepis AD, Moutsopoulos HM. You may have an autoimmune disorder if the level is high. The information posted on this website does not replace professional medical advice, but for general information purposes only. Because so many people who are completely healthy have an ANA, the test should only be run if a person has a symptom or better yet, multiple symptoms that potentially indicate the presence of an autoimmune disease like lupus, Sjgrens syndrome, systemic sclerosis, mixed connective tissue disease, etc. J Formos Med Assoc. 8600 Rockville Pike For example, a homogeneous pattern can be seen in patients with lupus or drug-induced lupus, while a nucleolar pattern can be seen more in patients with scleroderma or myositis, while a speckled pattern can be seen in patients with Sjogren syndrome and a centromere pattern can be seen in limited forms of scleroderma-like CREST syndrome. By itself, a positive ANA does not in any way mean you have an autoimmune disease or need treatment. The staining pattern is loosely associated with autoimmune diseases, but. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. For those with cancer, especially colon cancer or blood-related cancer such as leukemia or lymphoma, anemia may be one of the first signs of the disease. Your doctor will look for rashes and other signs that something is wrong. Youll also note that positive ANA, rheumatoid factor, and positive anti-SSB/La antibody positivity are not included in the new []. Examples include atopic dermatitis, non-allergic asthma, and pollen allergy. For an ANA test, a member of your health care team takes a sample of blood by inserting a needle into a vein in your arm. That also means that it is very rare to have lupus with a negative (normal) ANA. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. This is the perfect scenario, where an ANA would be useful. Advertising revenue supports our not-for-profit mission. HPV types 6 and 11 most often cause genital warts. Yes, a positive ANA can be seen in normal people. The most common immunofluorescence pattern was a fine dense speckled pattern. 6. Keywords: A 95 percent of all persons having this disease will have a positive test result for antinuclear antibodies. Neoplastic diseases may cause positive ANA. Unauthorized use of these marks is strictly prohibited. Top answers from doctors based on your search: Created for people with ongoing healthcare needs but benefits everyone. Ultimately it all boils down to this simple fact: doctors treat people not numbers. In that situation, it is helping rule in or rule out certain diagnoses. Never disregard or delay professional medical advice in person because of anything on HealthTap. The accumulating abnormal cells form a mass (tumor). Cancer and infections can also cause someone to have a positive ANA. This is usually happening in. Arthritis-like pain in one or more joints (but no or little joint damage) Red rash that frequently resembles a butterfly across the nose and cheek areas (malar rash) Low-grade fever Persistent fatigue, weakness Skin sensitivity to light Hair and weight loss Numbness or tingling in the hands or feet 2023 Rheumatologist OnCall All rights reserved. Dont get me wrong, these tests are important. [Investigation of antinuclear antibodies in chronic hepatitis B patients]. Bethesda, MD 20894, Web Policies But before that, lets talk about patterns because those are important too. All information contained within the Johns Hopkins Lupus Center website is intended for educational purposes only. Ann Med Interne (Paris). Epub 2005 Oct 25. Can electrical brain stimulation boost attention, memory, and more? Tell your doctor if lupus or other autoimmune diseases run in your family. For example, the presence of a speckled positive ANA indicates the presence of these specific autoantibodies, SSA, SSB, RNP, Smith, and Ku antibodies. Plantar warts. To view unlimited content, log in or register for free. In addition, more than one condition may be present at the same time. Antinuclear antibodies are found in many autoimmune diseases. Naturally, you will ask, What does the titer mean? The aim of this study was to evaluate the role of ANAs as a prognostic factor in CLL. FOIA Certain drugs affect the accuracy of the test, so bring your doctor a list of the medications you take. The positive test alone does not make the diagnosis of lupus. In these years, an increasing attention has been focussed in the relationship between tumours and autoimmunity. Here are 14 of the most common ones. Meng J, Yang G, Li S, Luo Y, Bai Y, Deng C, Song N, Li M, Zeng X, Hu C. Front Immunol. Now, some basic facts.. Lupus is diagnosed with a list of 11 indicators. Clinical features in the context of supportive bloodwork/imaging helps physicians determine whether one has an AI or is at risk of having an AI. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. It all depends on your symptoms, your physical examination, other routine test results and why the ANA was checked in the first place. 2011 Nov 18;50(3):497-502. doi: 10.1515/CCLM.2011.790. Rheumatoid Arthritis Is a condition that destroys the joints, causing pain and inflammations to the an individual. ANAs are antibodies that cause the immune system to attack the nuclei, or processing centers, of the body's own cells and tissues. By using our website, you consent to our use of cookies. Reviews on Radio Stations Hip Hop in Los Angeles, CA - Power 106, KCRW, Chocolate City -- 89. To learn more, please visit our, for several things such as rheumatologic diseases (e.g. Rheumatoid arthritis this causes joint damage, pain, and swelling. 2002 Mar-Apr;20(2):213-6. In most cases, a positive ANA test indicates that your immune system has launched a misdirected attack on your own tissue in other words, an autoimmune reaction. The result of your ANA test is one piece of information your doctor can use to help determine the cause of your signs and symptoms. As with lupus, the symptoms of lymphoma are varied and different people have differing lymphoma symptoms. There are different types of this disorder. Antinuclear antibodies (ANAS) are not common types of antibodies, though they can be traced in the blood of a man, they have the ability to attach themselves to some components found in the nucleus of the cells. HHS Vulnerability Disclosure, Help Lupus) and other chronic illnesses. In this article, I will discuss the most common causes for a positive ANA test as well as: ANA stands for antinuclear antibodies. As their name suggests, they are antibodies. For potential or actual medical emergencies, immediately call 911 or your local emergency service. 2023 Jan 2;24:401-437. doi: 10.1016/j.bioactmat.2022.12.027. I'd like to receive access to Harvard Health Online for only $4.99 a month. This is a low level. Perhaps there are even people in your environment who have never undergone chemotherapy or other diagnostics for the presence of cancer. 6 has suggested that in breast cancer they may be used as an aid to early diagnosis. At this point, theres no way for us to know whether this has happened, so the lab tech adds fluoresceinated antibodies to the mix. Both of these can be present particularly at low levels in Lyme []. Should I worry about a positive ANA test? Whether its clinically significant, is a whole different question. Conditions that usually cause a positive ANA test include: Systemic lupus erythematosus. Antinuclear antibody (ANA) is a blood test most often elevated in patients with systemic lupus erythematosus ("lupus"), Sjogren's syndrome, scleroderma, and other types of autoimmune diseases. Antinuclear antibodies are found in many autoimmune diseases. The ANA is calculated by taking a standardized cell from the lab and mixing it with a persons blood. In these situations, many organs can suffer when your bodys cells get attacked by your immune system. For example, a positive ANA to a titer of. 1:320 can be seen in 3% of healthy individuals without any sign of autoimmune disease. This decision guide is designed for persons with a positive antinuclear antibody (ANA) who would like to find out more about this test and what the test result may mean. You must understand why this test was ordered. It has no reliabilty for screening cancer. That means that the higher the titer of the ANA test, the more autoantibodies are present in the sample. For potential or actual medical emergencies, immediately call 911 or your local emergency service. A higher titer is helpful in confirming the diagnosis of several common diseases including lupus and type i, means that your immune system has launched a misdirected attack on your own. What are the most frequent causes of a positive ANA? 2006 May;25(3):341-6. doi: 10.1007/s10067-005-0059-3. ANA in rheumatic disease: SLE , drug-induced lupus erythematosus, Sjogren's syndrome, mixed connective tissue disease, progressive systemic sclerosis (scleroderma), ANA in non-rheumatic disease: autoimmune hepatitis, primary biliary cirrhosis, Graves' disease, Hashimoto's thyroiditis, hepatitis C, HIV infection. 2022 Apr 8;23(8):4151. doi: 10.3390/ijms23084151. Finally, some specific details about the ANA are important. The following is a list of common rheumatic and non-rheumatic conditions that are related to positive Antinuclear antibodies (ANA). Even patients with Rheumatoid arthritis can have a positive ANA. Ankylosing Spondylitis -Is HLA-B27 essential for diagnosis? Your medical journey will be easier if you have the proper medical support, education, and a true advocate.